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Stages of Breast Cancer

Cancer Stages

Breast cancer disrupts normal body functions, impacting the glandular tissue of the breast, including the lobes and their connecting ducts.

 

Cancer is classified in stages based on multiple factors, with the most common being TNM: 

  • T (original tumor)

  • N (in the nearby lymph nodes)

  • M (spreading to different parts of the body)

 

Stage 0: Cancer has not spread beyond the original cell layer in which it began (carcinoma in situ). 

 

Stage I - Stage IV: classification is based on how the cancer has metastasized to other areas of the body

 

Stage IV: When the cancer has spread to organs or distant tissue

 

Metastatic Breast Cancer (MBC): classified as late-stage (Stage IV) breast cancer that begins in the breast tissue and cascades (metastatic cascade) through the blood or lymphatic system to the bones, lymph nodes, lungs, liver, and brain. During this stage, palliative care focuses on improving quality of life and managing symptoms, including pain, cognitive deficits, shortness of breath, internal bleeding, and other negative effects of cancer 

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Image taken from The Johns Hopkins Hospital

References:

American Cancer Society. (2018). Cancer staging. Retrieved November 27, 2024, from https://www.cancer.org/cancer/diagnosis-staging/staging.html
Carreira, H., Williams, R., Dempsey, H., Stanway, S., Smeeth, L., & Bhaskaran, K. (2020a). Quality of life and mental health in breast cancer survivors compared with non-cancer
controls: A study of patient-reported outcomes in the United Kingdom. Journal of Cancer Survivorship, 15(4), 564–575. https://doi.org/10.1007/s11764-020-00950-3 
Kozlow, W., & Guise, T. A. (2005). Breast cancer metastasis to bone: Mechanisms of osteolysis and implications for therapy. Journal of Mammary Gland Biology and Neoplasia,
10(2), 169–180. https://doi.org/10.1007/s10911-005-5399-8 
Male, D. A., Fergus, K. D., & Cullen, K. (2016). Sexual identity after breast cancer. Current Opinion in Supportive & Palliative Care, 10(1), 66–74.
https://doi.org/10.1097/spc.0000000000000184 
Przezdziecki, A., Sherman, K. A., Baillie, A., Taylor, A., Foley, E., & Stalgis‐Bilinski, K. (2012). My changed body: Breast cancer, body image, distress and self‐compassion.
Psycho-Oncology, 22(8), 1872–1879. https://doi.org/10.1002/pon.3230 
Side effects of breast cancer treatment and how to manage them. National Breast Cancer Foundation. (2024, July 1).
https://www.nationalbreastcancer.org/side-effects-of-breast-cancer-treatment-and-how-to-manage-them/ 
Velasco Yanez, R. J., Carvalho Fernandes, A. F., de Freitas Corpes, E., Moura Barbosa Castro, R. C., Sixsmith, J., & Lopes-Júnior, L. C. (2023). Palliative care in the treatment of
women with breast cancer: A scoping review. Palliative and Supportive Care, 1–18. https://doi.org/10.1017/s1478951523001840 
Yao, N., Li, W., Liu, T., Siyin, S. T., Chen, X., Wang, W., Duan, N., Chen, Y.-T., & Qu, J. (2020). Primary tumor removal improves the prognosis in patients with stage IV breast
cancer: A population-based study (Cohort Study). International Journal of Surgery, 83, 109–114. https://doi.org/10.1016/j.ijsu.2020.08.056

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